Severe allergic reactions may affect up to 1 in 10 000 people the signs include swelling of. Possible systemic effects include cushing s syndrome cushingoid features adrenal suppression growth retardation in children and adolescents decrease in bone mineral density and more rarely a range of psychological or behavioural effects including psychomotor hyperactivity sleep disorders anxiety depression or aggression particularly in children. Symptoms such as vomiting drowsiness nausea headache tiredness loss of appetite low blood sugar level and fitting.
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